A Case Report on Haloperidol-induced Neuroleptic Malignant Syndrome (nms)

Neuroleptic malignant syndrome (NMS) is one of the life-threatening adverse drug reactions caused by dopamine receptor-antagonists, such as high-potency typical antipsychotics. A case of a 16-year-old male patient who developed NMS after administration of haloperidol is reported. He demonstrated classic features of NMS, including generalized muscle rigidity, rhabdomyolysis, fever, altered mental status, autonomic instability, and increasing creatine phosphokinase (CPK) level and leukocyte count. His NMS resolved after proper management, including cessation of haloperidol and the initiation of supportive care therapy and pharmacological agent, was given. The pathogenesis, clinical presentation, and proper management of NMS are discussed in this case report.